For an oocyte to get ready for fertilization and advancement into an embryo, the ideal set of genes ought to be turned on. Namekawa suspected this pre-programming from the oocyte genome occurs in quite a few phases — the initial a person starting up within the time a female is born. He believed that chromatin remodeling proteins did Significantly of the work, by shifting spools all around.
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This protein may perhaps “set up and manage the chromatin state,” claims Namekawa — maintaining the spools set up and also the oocytes genetically primed as being the mouse matures.
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